Dr. Sanjay Pujari talks about once daily Darunavir/ Ritonavir for the management of HIV. He starts with the basics of Darunavir/Ritonavir, its role in patients, discuss few special situations and novel strategies using Darunavir/Ritonavir. Darunavir inhibits the HIV protease enzyme by forming an inhibitor-enzyme complex thereby Darunavir is contraindicated with the following medications: dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, oral midazolam, triazolam, lovastatin, simvastatin, and rifampin